Applications are welcomed for an exciting new training prospect in the molecular and cellular biology of intracellular parasitism. Toxoplasma gondii is an opportunistic protozoan parasite that can cause severe disease (encephalitis, retinitis, birth-defects) in humans and animals. Considered a paradigm for intracellular parasitism, T. gondii is easily grown in culture, has excellent animal models, and is readily amenable genetic manipulation.

This newly-funded NIH R01 project involves uncovering proteolytic mechanisms of parasite infection, focusing the regulation of physiology and function of a lysosome-equivalent digestive organelle in the parasites. Recently, our lab published a research article in PLOS Pathogens, characterizing the role of a Toxoplasma chloroquine resistance transporter (TgCRT) in the mediation of morphology and physiology changes in this organelle, further affecting parasite invasion. We aim to identify the molecular mechanism by which the digestive organelle maintains its optimal microenvironment for parasites infection by using state-of-the-art molecular biology, biochemistry, cell biology techniques along with animal models. The successful candidate will have an opportunity to help lead this project, including developing new strategies for interfering in the biogenesis of Toxoplasma digestive vacuole en route to a career as an independent investigator.

Candidates must have a Ph.D. and/or M.D., or equivalent degree. Previous experience in parasitology is not necessary. Competitive applicants will have a record of outstanding achievements and the potential for success as a leader in academic or industry research.

Clemson University is located on Lake Hartwell near the Blue Ridge mountains in beautiful Upstate South Carolina near the Appalachian mountain range. Clemson is a research university with a strong commitment to teaching, research, and student success, ranking 20th among national public universities by U.S. News & World Report.

Please send by e-mail a cover letter stating interests and career goals, a C.V. including list of publications, and the contact info for three individuals willing to provide reference letters to Zhicheng Dou, zdou@clemson.edu.

Clemson University is an AA/EEO employer and does not discriminate against any person or group on the basis of age, color, disability, gender, pregnancy, national origin, race, religion, sexual orientation, veteran status or genetic information. Clemson University is building a culturally diverse faculty and staff committed to working in a multicultural environment and encourages applications from minorities and women.

2. Lab Specialist 

This Lab Specialist I position will assist in a molecular parasitology research lab at Clemson University to study the proteolytic mechanism of Toxoplasma infection, a eukaryotic parasitic pathogen. The incumbent will work with the Principal Investigator and other lab members in bench research. The Principal Investigator and lab staff will train the incumbent to perform their duties as required and will closely monitor the progress.

The responsibilities of this position include, but are not limited to:

  • Carry out cell culture procedures, in vitroassays and maintain mammalian

cell lines and Toxoplasma gondii parasite strains.

  • Perform and assist in experiments using standard molecular biology

techniques, such as PCR, molecular cloning, western blotting, and protein

expression and purification.

  • Prepare tissue culture reagents and media. Prepare commonly used reagents

and buffers for molecular biology.

  • Operate various preparative and analytical instrumentations.
  • Unpack received items, clean and organize the lab.


  • BA/BS in Biological Sciences, Biochemistry, Microbiology, OR related majors
  • Research experiences in molecular biology preferred
  • Previous tissue and cell culture experience preferred

Pay and Work Schedule:

This is a full-time position. The annual starting salary is $25,000 – 28,000, commensurate with experience.

How to apply:

Please submit your cover letter and resume as a single attachment to Dr.

Zhicheng Dou via zdou@clemson.edu when applying. Review of materials will

begin immediately and continue until the position is filled.

3. Graduate students for Ph.D. degree

I am looking for talented undergraduate students with a great passion in biomedical research to join my lab for pursuing Ph.D. degrees in Biological Sciences or Microbiology programs. If you are interested in this opportunity, please send an email with a single pdf attachment, including a personal statement, CV, and transcripts, to zdou@clemson.edu.